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The Value of P16, Ki-67 in the diagnosis of cervical squamous intraepithelial lesion
XIAO Gang, YE Yu Qing, WEI Jie Zhen, XIAN Li Fang, GU Jie Ming
Medical Journal of Kiang Wu ›› 2022, Vol. 22 ›› Issue (1) : 42-43.
PDF(2394 KB)
PDF(2394 KB)
The Value of P16, Ki-67 in the diagnosis of cervical squamous intraepithelial lesion
XIAO Gang*, YE Yu Qing, WEI Jie Zhen, XIAN Li Fang, GU Jie Ming
Objective To study the significance of P16, Ki-67 testing in grading diagnosis of cervical squamous intraepithelial lesion. Methods 66 cases of cervical biopsy specimens from colposcope were collected. The expressions of P16, Ki-67 were evaluated by immunohistochemical staining. Results The positive rates of P16 in chronic cervicitis, low-grade squamous intraepithelial lesion(LSIL) and high-grade squamous intraepithelial lesion(HSIL) were 0.00%, 6.90% and 100%. The positive rates of Ki-67 in chronic cervicitis, LSIL and HSIL were 0.00%, 3.45% and 95.45%. The positive rates of P16 and Ki-67 in HSIL were higher than in chronic cervicitis and LSIL (P<0.05). Conclusion P16 and Ki-67 testing play an important significance in grading diagnosis and treatment of cervical squamous intraepithelial lesions. The specificity of P16 is higher in the diagnosis of the cervical squamous intraepithelial lesion.
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